Lysyl Oxidase Like-2 Contributes to Renal Fibrosis in Col4A3/Alport Mice
Dominic Cosgrove, Brianna Dufek, Daniel Meehan, Duane Delimont, Michael Hartnett, Gina Samuelson, Michael A. Grafton, Grady Phillips, Deidre A. MacKenna, Gretchen Bain
November 1-5, 2017 Kidney Week, New Orleans, LA

PAT-409, a Novel Inhibitor of Autotaxin, Reduces Fibrosis in Both Mouse and Rat Models of NASH
Deidre A. MacKenna, Kristen E. Shannon, Katherine T. Nguyen, Gina L. Ma, Lance Goulet, Dove Lonergan, John H. Hutchinson, Jilly F. Evans, Gretchen Bain
October 20, 2017 AASLD, Washington DC

A Novel Small Molecule LOXL2 Inhibitor PAT-1251 Potently Suppresses Hepatic Stellate Cell Activation and Liver Fibrosis in Mouse Models of Biliary Disease
Ping An, Kahini Vaid, Guangwang Wei, Yi Lin, Gretchen Bain, Yury Popov
October 20, 2017 AASLD, Washington DC

Development of PAT-1251, a Small Molecule Inhibitor of LOXL2
John H. Hutchinson, Ph.D. Invited Speaker
September 27, 2017 Discovery on Target, Boston

PAT-1251, a Mechanism-Based Small Molecule Inhibitor of LOXL2, as a Potential Anti-Fibrotic Treatment for IPF
Deidre A. MacKenna, Martin W. Rowbottom, Angelina M. Santini, Kristen E. Shannon, Gina L. Ma, Katherine Nguyen, Janice Darlington, Imelda Calderon, Christopher D. King, John H. Hutchinson, Kevin Holme, Susan E. Hazel, Jilly F. Evans & Gretchen Bain
August 21-23, 2017 IPF Summit, Boston

The Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)
Martin W. Rowbottom, Gretchen Bain, Imelda Calderon, Taylor Lasof, David Lonergan, Andiliy Lai, Fei Huang, Janice Darlington, Patricia Prodanovich, Angelina M. Santini, Christopher D. King, Lance Goulet, Kristen E. Shannon, Gina L. Ma, Katherine Nguyen, Deidre A. MacKenna, Jilly F. Evans, and John H. Hutchinson
2017 J Med Chem60 (10), pp 4403–4423

A Mechanism-Based Small Molecule Inhibitor of LOXL2 that Displays Robust Anti-Fibrotic Efficacy in a Mouse Bleomycin Model of Lung Fibrosis
Deidre A MacKenna, Martin W. Rowbottom, Kristen E. Shannon, Gina L. Ma, Katherine Nguyen, Janice Darlington, Imelda Calderon, Christopher D. King, John H. Hutchinson, Jilly F. Evans, and Gretchen Bain
March 26-30, 2017 Keystone Symposia: Injury, Inflammation and Fibrosis, poster

Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX
John H. Hutchinson, Martin W. Rowbottom, David Lonergan, Janice Darlington, Pat Prodanovich, Christopher D. King, Jilly F. Evans, and Gretchen Bain
2017 ACS Med Chem Lett, 8(4), pp 423–427

Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis
Gretchen Bain, Kristen E. Shannon, Fei Huang, Janice Darlington, Lance Goulet, Patricia Prodanovich, Gina L. Ma, Angelina M. Santini, Adam J. Stein, Dave Lonergan, Christopher D. King, Imelda Calderon, Andiliy Lai, John H. Hutchinson, and Jilly F. Evans
2016 J Pharm Exp Therapeutics, 360(1): 1-13

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding
Adam J. Stein, Gretchen Bain, Pat Prodanovich, Angelina M. Santini, Janice Darlington, Nina M. P.  Stelzer, Ranjinder S. Sidhu, Jeffrey Schaub, Lance Goulet, Dave Lonergan, Imelda Calderon, Jilly F. Evans, and John H. Hutchinson
2015 Molecular Pharmacology 88: 982-992