The Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)
Martin W. Rowbottom, Gretchen Bain, Imelda Calderon, Taylor Lasof, David Lonergan, Andiliy Lai, Fei Huang, Janice Darlington, Patricia Prodanovich, Angelina M. Santini, Christopher D. King, Lance Goulet, Kristen E. Shannon, Gina L. Ma, Katherine Nguyen, Deidre A. MacKenna, Jilly F. Evans, and John H. Hutchinson
2017 J Med Chem60 (10), pp 4403–4423

A Mechanism-Based Small Molecule Inhibitor of LOXL2 that Displays Robust Anti-Fibrotic Efficacy in a Mouse Bleomycin Model of Lung Fibrosis
Deidre A MacKenna, Martin W. Rowbottom, Kristen E. Shannon, Gina L. Ma, Katherine Nguyen, Janice Darlington, Imelda Calderon, Christopher D. King, John H. Hutchinson, Jilly F. Evans, and Gretchen Bain
March 26-30, 2017 Keystone Symposia: Injury, Inflammation and Fibrosis, poster

Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX
John H. Hutchinson, Martin W. Rowbottom, David Lonergan, Janice Darlington, Pat Prodanovich, Christopher D. King, Jilly F. Evans, and Gretchen Bain
2017 ACS Med Chem Lett, 8(4), pp 423–427

Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis
Gretchen Bain, Kristen E. Shannon, Fei Huang, Janice Darlington, Lance Goulet, Patricia Prodanovich, Gina L. Ma, Angelina M. Santini, Adam J. Stein, Dave Lonergan, Christopher D. King, Imelda Calderon, Andiliy Lai, John H. Hutchinson, and Jilly F. Evans
2016 J Pharm Exp Therapeutics, 360(1): 1-13

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding
Adam J. Stein, Gretchen Bain, Pat Prodanovich, Angelina M. Santini, Janice Darlington, Nina M. P.  Stelzer, Ranjinder S. Sidhu, Jeffrey Schaub, Lance Goulet, Dave Lonergan, Imelda Calderon, Jilly F. Evans, and John H. Hutchinson
2015 Molecular Pharmacology 88: 982-992